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Cellex-C        2006-10-19 23:05:42     Bookmark and Share

Vitamin C as a skin preserver - Duke University Medical Center research

Vitamin C As a Skin Preserver

The prospect of using a cream containing vitamin C against sunburn and as an anti-cancer bulwark is inching closer to reality.

Researchers have completed a product containing high concentrations of vitamin C for which a patent is being applied.

Among topical vitamin C's surprising properties, the inventors attest, are its protective qualities and the anti-inflammatory effects. Once applied to the skin, they say, it can't be washed off, sweated off, or rubbed off.

Dr. Sheldon Pinnell, chief of dermatology at Duke University Medical Center in Durham, North Carolina, one of the product's proponents, said that in experiments topical vitamin C. afforded more protection than other substances. Traditional sunscreens, he explained, are formulated to absorb certain ultraviolet wavelenghts likely to damage skin. In contrast, vitamin C appeared to have a wavelenght-independent effect that lasted three days, even when pigs were scrubbed with soap.

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Topical vitamin C, Dr. Pinnell asserted, when used by itself might prevent sun damage without blocking vitamin D synthesis, which occurs when ordinary sunscreens are used. It might also stimulate melanin production without damaging neighboring cells, another dermatologist, James Leyden said. Safer tanning, he predicted, would make the new product a commercial success.

Can the preparation quench oxygen free radicals? If that theory is correct, speculates Dr. Pennell, Topical Vitamin C preparation might help guard against other hazards of life in an oxygen-rich atmosphere, such as wrinkling and skin cancers.

Should a patent be granted, the Food and Drug Administration will probably be asked to approve the preparation for prescription use, Dr. Pinnell predicted.

 

CELLEX-C
----------------------------------------------------------

Dr. Sheldon Pinnel , chairman of Dept. Derm at Duke Univ. did the
research on Celex-C and started the present company for distribution
of the product.  To my knowledge, he has never published any
supporting data for his claims, which is unfortunate.  One of my
patients used this product when it was first available through
Canada.  I photographed her during the course of a year and could not
document any improvement in her solar elastosis.  Since then I have
followed other patients who have used the product and still can not
see any benefit.  How can we as dermatologists recommend a product
that has no supportive evidence for effectiveness dispite one of our
colleagues pushing it?

John Jennings, MD 

 

The scientists at SkinCeuticals were the first to bring you a truly revolutionary antioxidant formulation - stable high concentration topical vitamin-C. This technology was the culmination of over a decade of research by Dr. Sheldon Pinnell, who developed and patented a stable laboratory formulation of L-ascorbic acid. Shortly thereafter, Dr. Mostafa Omar perfected a stable, elegant form of vitamin-C for use in cosmetics. Acclaimed by dermatologists worldwide as the best available stable L-ascorbic acid formulation, Dr. Omar's exceptional technology is exclusively available in SkinCeuticals products.

Dr. Sheldon Pinnell is the J. Lamar Callaway Professor of Dermatology at Duke University Medical Center. He is the world's foremost authority on topical vitamin-C and other topical anti-oxidants. He has published numerous articles and abstracts on these subjects, and is the inventor of four patents. Dr. Mostafa Omar is a professor of Pharmacognosy at the University of Rhode Island. He is a natural product chemist with unprecedented formulation capabilities.

Print or view the curriculum vitae of Dr. Sheldon Pinnell or Dr. Mostafa Omar. Adobe Acrobat Reader is required to view the pdf documents.

 

 

Founded in 1994, SkinCeuticals is dedicated to the research and development of cutting edge dermatology products.
 
SkinCeuticals products are the culmination of decades of research by two scientists, Dr. Sheldon Pinnell, professor of Dermatology at Duke University Medical Center, and Dr. Mostafa Omar, professor of Pharmacognosy at the University of Rhode Island. Dr. Pinnell is the world's foremost authority on topical vitamin-C and other topical anti-oxidants.

SkinCeutical products are sold through the world??eading dermatologists, plastic surgeons, obstetricians, gynecologists, and pharmacies.
 
Recent research conducted by Dr. Sheldon Pinnell at Duke University Medical Center shows that applying vitamin-C to the skin can:
Provide anti-oxidant protection
Prevent photo-aging
Stimulate collagen production

 

 

The SkinCeuticals line of products, a pioneer in topical Vitamin C and some of the best sunscreens on the market, was developed by Dr. Sheldon Pinnell. In 1992 he conducted a series of studies that demonstrated the many benefits of topical Vitamin C in the stable form of L-ascorbic acid.

SkinCeuticals topical Vitamin C products help to improve elasticity and firmness, fight oxy radical damage (skin damage caused by the sun), and minimize the appearance of fine wrinkles. This line also includes superb moisturizers which help to replenish the skin's moisture while providing antioxidant protection against free radical damage caused by environmental elements such as the sun and air pollution. Finally, SkinCeuticals sunscreens provide a broad range of protection against UVA and UVB damage and are excellent for prolonged sun exposure as well as everyday use.

 

 

SkinCeuticals Skin Care
Dr. Sheldon Pinnell started the SkinCeuticals line after his falling out with the skin-care company Cellex-C. The Cellex-C line of skin-care products originated around a $70-an-ounce product containing a form of vitamin C called L-ascorbic acid that was researched by Dr. Pinnell, although Duke University holds the patent for that ingredient. According to Dr. Pinnell, Cellex-C products use an unstable form of L-ascorbic acid; and of course, Dr. Pinnell¡¯s line contains the stable, good form. Aside from the disagreement between these two companies, L-ascorbic acid is considered a potent antioxidant and anti-inflammatory (Sources: Bioelectrochemistry and Bioenergetics, May 1999, pages 453–461; and International Journal of Radiation Biology, June 1999, pages 747–755), but claims that it can eliminate or prevent wrinkles when applied topically are not substantiated in any published studies. In addition, it is stable only in a formulation with a low pH, and that is potentially irritating for skin (Source: Dermatologic Surgery, February 2001, pages 137–142).

The propaganda about this ingredient, or any ¡°must-have¡± cosmetic ingredient, is intended to sell skin-care products, not to offer women truly viable options for addressing the health of their skin, though stable vitamin C certainly has merit for skin. Keep in mind that there are lots of good antioxidants, and vitamin C in any or all of its forms is not the ¡°best¡± one.

As research reveals more positive information about the role antioxidants play in helping skin repair itself and maintain a healthy appearance and optimal function, it is more important than ever to make sure the skin-care products you¡¯re considering have plenty of them. They won¡¯t get rid of wrinkles or replace sunscreen, but they can offer increased sun protection, and in theory can help the skin to defend itself from free-radical damage while maintaining its integrity. Despite this good news, many cosmetic companies over-inflate the benefits of antioxidants, making claims about reversing aging, building collagen, and feeding the skin. [The complete SkinCeuticals review is contained in my book, Don't Go to the Cosmetics Counter Without Me, which may be purchased from my site.]



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